People infected with pathogenic H7N9 virus was discovered a new mechanism

Institute of Microbiology and Epidemiology, Academy of Military Medical Zhou Yusen team Experimental Animal Center, the hospital had a joint forest team, Institute of Basic Medical team Li Yan, chief scientist at Fudan University in Shanghai Shi Bo Jiang team and Germany Inflarx Gmbh company Guoren Feng scientific research team found that people infected H7N9 bird flu virus, a new pathogenic mechanisms.

The virus is spread by infection, can lead to a class of human immune proteins – excessive activation of the complement system, causing acute lung injury.

They Based on this discovery, new therapeutic strategies through an antibody for the anaphylatoxin C5a complement molecule drugs to regulate the level of expression, shown to greatly reduce the “inflammatory factors storm”, significantly reduced lung pathological injury, which can effectively treatment of severe pneumonia caused by a viral infection.

The results were published in the international field of infectious disease research authoritative latest issue of the academic journal “Clinical Infectious Diseases.” THE ACADEMY papers and co-first author Dr. Zhao Guangyu played an important role in this study.

 
Complement is present in serum and tissue fluid in the heat of a class of a group of proteins with enzymatic activity. Early in the 19th century, human scientists confirmed that the blood contains a heat-labile components, can assist and supplement specific antibodies, immune-mediated lysis, hemolysis, so called complement.