Japanese researchers have developed an antibody to reduce the lead to Alzheimer’s disease abnormal Tau protein in the brain, and successfully improved the memory of mice. This will help develop the treatment of Alzheimer’s disease drugs.
Research shows that the brain in Alzheimer’s patients will be two pathological changes, one of which is hyperphosphorylated Tau protein after, in the formation of intracellular accumulation of neurofibrillary tangles, neurofibrillary tangles closely related to the death of nerve cells and cognitive dysfunction. Osaka City University research team developed will be able to phosphorylated Tau protein binding of antibodies to clear, to about 10 abnormal Tau protein in the brain of the mice injected once a week, each injection of 1 mg, the results of experiments succeeded in reducing abnormal Tau protein in rat brain, preventing the nerve cell death.
To investigate the memory of mice, researchers gave mice in a maze swimming pool. It was found that injection of a group of non-injected antibody is only about half the average time a set of antibodies. Off papers have been published in the United States, “Annals of Neurology, Clinical and Translational” online edition.