Drugs and vaccines
One of the biggest influence B lymphocyte biology is generated hybridomas invention, which is a produced antibody can be immortalized cell lines. In 1975, Georges from the MRC Laboratory of Molecular Biology in Cambridge, England in K? Hler and César Milstein Hua reported that their B cells with a myeloma cell fusion, the resulting hybrid cells can continuously produce specific antibodies. This is the origin of the monoclonal antibody technology, and K? Hua hler, Milstein and Niels Jerne get 1984 Nobel Prize in Physiology or Medicine.
The results of the impact arising again can not be overstated how overrated. Over the next few years, monoclonal antibodies throughout all corners of Experimental Biology. These are a class of molecules that can be used to identify, separate researchers interested in almost any molecule or potential cell-specific reagents. Clinically, the monoclonal antibodies has become one of the most powerful diagnostic and treatment modalities.
Cooper also found that clonal selection theory to answer the most fundamental question basis, that is how to generate clonal diversity. In 1976, Susumu Tonegawa illustrates the problem: B cell by binding to three kinds of gene fragments, “called” a plurality of series of antibodies.
Ultimately, these antibodies get to elaborate on the chemical level, now on genes, cells and tissue levels also have a better understanding. By the mid-1980s, the properties of T cell clones also been explained. By discovering B cells and T cells, Cooper and his colleagues opened a series of landmark discovery, and eventually unify the field of chemistry and molecular camp.
Leave a Reply