Nature magazine published an article commemorating 50 years found that B lymphocytes

Explanatory power for the two lymphocyte immune deficiency disease model is huge. Because gamma globulin associated with the X chromosome deficiency in patients with defects in antibody production, but normal in cell-mediated immunity, the disease so they can probably be attributed to defects in B cell development. On the contrary, Switzerland type cellular immunity and antibody-based immunity are seriously lacking without agammaglobulinemia, probably before the cell body by a defect of T cells and B cells are affected due. It is not surprising that, compared to immunologists, clinicians Cooper found more acceptable.

Next, the most important issue facing the Cooper on the same balloon lumen same effect organ found in mammals. In the ensuing nearly 10 years, the relevance and versatility of the research has been controversial.

Find and the role of the upper chamber of the same capsule proven extremely difficult organ in mammals. Initially, Cooper and his colleagues suspected intestinal tissue is a source of B cells. They spend a great effort in this dead end.

In 1974, the answer is finally surfaced. At that time, Cooper and Martin Raff from University College London, John Owen embryonic liver cells obtained from mice 14 days of pregnancy. After 4-7 days of incubation, B cells produce. At the same time, by Gustav Nossal from WEHI and the University of Geneva, Switzerland, a team led by Pierre Vassalli using mouse bone marrow cells had similar findings. In other words, the formation of blood or blood tissue acts as a bursa in chickens role in mammals.

By the late 1970s, this kind of understanding for the different types of lymphocytes began to change in the treatment of leukemia and lymphoma. Today, the origin of these tumor cells can be used to classify cancer and to develop different approaches to treatment. Therefore, acute lymphocytic leukemia may be derived from B cells or T cells, or that neither, instead of Hodgkin and Burkitt’s lymphoma derived B cells. The effect of different treatments for these tumors how often and their classification are closely related.