Nano-medicine faster healing for wound

David and his discovery while previously called fidgetin-like 2 (FL2) enzyme slows the various callus cells to the wound arrival rate, thereby interfering with the process of callus. FL2 will cut off the structure called mircrotubules of. Intracellular microtubules is a miniature of the pipeline, supporting cell structure, but also can serve as a platform to transport material between cells. FL2 may help prevent abnormal tissue growth, but its function is not fully clear.

The researchers said temporarily suppress FL2 can improve wound healing level, so they made a drug to inhibit this enzyme. The drug use “silence RNA” molecules to inhibit gene expression FL2.

Cells grown in the laboratory dish tests showed that the drug can make the skin more than double the rate of cell migration. However, if used directly in the wound, the drug will quickly degrade extracellular environment before repressor FL2.

This allows researchers must try to protect the drug from degradation, they nanoparticle drugs into the capsule and then transported to the cell needs in-depth site. Such nanoparticles than human or mouse cells about 50 times smaller.

When applied to cuts and burns in mice, the researchers found that the nanoparticle therapy to wound healing time in half. David said he hoped that after a few months of treatment experiment in pigs, because pigs and humans are more similar to the skin.

If the experiment is to proceed smoothly, the US Food and Drug Administration (FDA) approved the drug may be applied to human beings in a few years, David told Live Science website. Approval of external use is usually shorter than oral drugs, he said.

But in addition to topical new drug may also be taken orally.

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