Published online – a study “Nature Genetics” published on the main cause of cervical cancer – human papillomavirus (HPV) virus integration site map. Viral integration is viral DNA into the host DNA itself in the process, which is the HPV infection leads to one of the major risk factors for cervical cancer generated.
Ding Ma, who use high-throughput detection of viral integration methods found 3667 HPV integration sites in more than 100 cancer samples. They identified nine genes there are integration site at least five samples, there are additional 33 gene integration site at least four samples. Integrated into the genome of the virus according to the position, the virus can lead to integration of host gene expression or loss or increase, thereby increasing the risk of cancer. The study found or could help researchers understand the prevalence of early stages of cervical cancer, cervical cancer screening and improved.
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