Fibroblast and wound repair

Bone trauma repair

The most simple and common bone trauma is the fracture, the healing process to go through the inflammatory reaction, cleaning, fibrous callus and bony callus 4 stages. Different stages of participation of different cell bodies. Fibroblast appeared in the local hematoma of fractures from the third day after fracture, and existed in the interstitial space and around the fracture 5 days after fracture, which is the main cell component involved in the fibrotic callus. At this stage Fibroblast proliferation and proliferation on the one hand a large number, on the one hand, the synthesis and secretion of large amounts of collagen type Ⅰ, the granulation tissue gradually become loose connective tissue, the fracture will be surrounded by broken ends to form the fracture ends of the huge fibrous bone scab. However, this fibrous connective tissue composed mainly of innumerable Fibroblast and abundant granulation tissue does not evolve into scar tissue that is common in repairing wounds of other tissues. Instead, it is continuously deposited in the inside by calcium salt crystals and gradually evolves into Bony callus, so that local repair of fractures to achieve bone healing, restore the structure of bone tissue. At this point, the fracture healing only bone tissue and no longer exist Fibroblast.

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